Figure 5.

Neutrophil migration in thioglycollate-induced peritonitis. PSGL-1–deficient mice with matched controls and P-selectin–deficient mice with matched controls were studied in parallel. Absolute neutrophil counts in the peritoneal exudate were determined at the indicated times after induction of experimental peritonitis with thioglycollate. An expanded comparison at 2 h is presented in the inset. (A) PSGL-1^−/− mice (•, and [inset] black bars) and matched wild-type control mice (○, and [inset] white bars). (B) P-selectin^−/− mice (▪, and [inset] black bars) and matched wild-type control mice (□, and [inset] white bars). Each data point represents the average of the results of 8–10 mice. Data are presented as mean ± SEM. Differences were statistically significant (*P < 0.001; ^# P = 0.002) compared with respective wild-type controls.