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. 1999 Dec 20;190(12):1825–1836. doi: 10.1084/jem.190.12.1825

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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TS/CM restores growth of IL-6–dependent DS-1 B lymphoma cells. PBMCs and T-24 cells were incubated without (CM) or with (TS/CM) TS for 24 h, and the resulting conditioned media were used at the indicated dilutions to supplement IL-6–free medium for DS-1 cells. A neutralizing IL-6 rabbit IgG at 1 μg/ml was added to each dilution of the TS/CM (TS/CM + IL-6 Ab). Normal rabbit IgG had no effect on the growth-promoting action of TS/CM (data not shown). TS was added directly to the IL-6–free growth medium at 1 μg/ml, which corresponds to 1:5 dilution shown on the x-axis. The plot above is for TS-CM from PBMC cultures, but similar results were obtained with T-24 cultures. Experiment repeated twice with similar results.