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Human CRP Increases Myocardial Infarct Size in Rats
| Treatment | No. treated | Day 5 survivors | Infarct size mean (SD) | Bonferroni t test vs. controls |
|---|---|---|---|---|
| % | ||||
| Experiment 1 | ||||
| Buffer only | 5 | 5 | 14.5 (1.1) | – |
| Human CRP | 5 | 4 | 21.2 (2.0) | P = 0.0007 |
| Experiment 2 | ||||
| Buffer only | 3 | 3 | 12.8 (0.9) | – |
| Human SAP | 5 | 5 | 12.4 (1.9) | NS |
| Human CRP | 5 | 3 | 17.6 (0.4) | P = 0.0022 |
Human CRP or SAP was injected intraperitoneally at 40 mg/kg.
