Table 2.

Complement Dependence of the Enhancement of Infarct Size by Human CRP

Treatment	No. treated	Day 5 survivors	Infarct size mean (SD)	Bonferroni t test vs. controls
			%
Buffer only	8	8	14.3 (1.2)	–
Human CRP	5	3	19.7 (1.6)	P = 0.0020
Complement
depletion	5	5	6.5 (0.9)	P = 0.0000
Complement
depletion +
human CRP	6	6	6.9 (0.3)	P = 0.0000

Human CRP at 40 mg/kg was injected intraperitoneally 1 h after coronary artery ligation and then at 24-h intervals until all rats were killed 5 d later; controls received buffer alone. Parallel groups had been decomplemented by intraperitoneal injection of cobra venom factor at 250 U/kg 24 h before coronary artery ligation.