Table 3.
Cardioprotective Effect of Complement Depletion in Myocardial Infarction
| Cobra venom factor treatment | No. of rats | Infarct size on day 5 mean (SD) | Bonferroni t test vs. controls |
|---|---|---|---|
| % | |||
| None, buffer only | 4 | 17.7 (1.9) | |
| 24 h before coronary ligation | 4 | 7.0 (1.2) | P = 0.0002 |
| 0.5 h after coronary ligation | 4 | 9.7 (1.1) | P = 0.0007 |
| 2 h after coronary ligation | 4 | 9.5 (1.6) | P = 0.0011 |
| 6 h after coronary ligation | 4 | 16.9 (2.2) | NS |
| 24 h after coronary ligation | 4 | 16.9 (1.2) | NS |
Cobra venom factor at 250 U/kg was injected intraperitoneally at the times shown in relation to coronary artery ligation; controls received buffer only. All rats were killed after 5 d for estimation of infarct size. One-way analysis of variance, total DF = 23, F = 36.45, P = 0.0000.