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. 1999 Dec 6;190(11):1697–1710. doi: 10.1084/jem.190.11.1697

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Altered T and B cell organization, intense germinal center reactions, decreased number of dendritic cells, and increased number of plasma cells in the spleen of BAFF-Tg mice. A control mouse is shown in A, C, E, and G and a BAFF-Tg mouse in B, D, F, and H. B cells are blue and T cells brown (A and B). Germinal centers are marked with an arrow (C and D). Only a few residual germinal centers are seen in control mice (C). CD11c-positive dendritic cells are brown and appear in the T cell zone, bridging channels and the marginal zone (E). Very few are present in BAFF-Tg mice (F). Syndecan-1–positive plasma cells were only detectable in the red pulp of BAFF-Tg mice (H) but not control mice (G). These pictures are representative of at least 12 BAFF-Tg mice analyzed and 12 control mice. 100× except C and D (50×). B, B cell follicle; T, periarteriolar lymphocyte sheath; WP, white pulp; RP, red pulp.

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