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. 1999 Dec 6;190(11):1637–1646. doi: 10.1084/jem.190.11.1637

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Lesion scores in mice infected with wild-type or gC mutant viruses. The left panels (A, C, and E) show disease scores ± SEM at the inoculation site, and the right panels (B, D, and F) show disease scores ± SEM at the zosteriform spread site. A and B demonstrate disease scores in complement-intact mice (normal mice), C and D in C3 knockout mice, and E and F in C3 knockout mice reconstituted with human C3. WT, virus NS; C5, NS-gCΔC5/P; C3, NS-gCΔC3; C5,C3, gC double mutant virus NS-gCΔC5/P,C3. The numbers of animals evaluated in each group are indicated in the legends at right.