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. 1999 Dec 6;190(11):1605–1616. doi: 10.1084/jem.190.11.1605

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Development of CD8⁺ cells in the E47-deficient mice requires MHC class I expression. E47-deficient mice were bred onto the β2M-deficient background, and 4–6-wk-old littermates were analyzed for CD4, CD8, and TCR expression. Thymocytes (A) and splenocytes (B) from E47-deficient and heterozygous littermates on a β2M-deficient or heterozygous background were analyzed by staining with anti-CD8α and anti-CD4. The numbers in each quadrant indicate the percentage of thymocytes in that population. The CD4/CD8 ratios for the spleens are indicated under the FACS^® plots in B.

Development of CD8⁺ cells in the E47-deficient mice requires MHC class I expression. E47-deficient mice were bred onto the β2M-deficient background, and 4–6-wk-old littermates were analyzed for CD4, CD8, and TCR expression. Thymocytes (A) and splenocytes (B) from E47-deficient and heterozygous littermates on a β2M-deficient or heterozygous background were analyzed by staining with anti-CD8α and anti-CD4. The numbers in each quadrant indicate the percentage of thymocytes in that population. The CD4/CD8 ratios for the spleens are indicated under the FACS^® plots in B.