Figure 1.
Effect of anti-OX40L, -CD70, -CD30L, and –4-1BBL mAb on the course of L. major infection. BALB/c mice (A and C) or C57BL/6 mice (B and D) were infected with 5 × 106 stationary phase promastigotes subcutaneously in the hind footpad. Mice were treated with 300 μg of anti-OX40L mAb (○, A and B), anti-CD70 (▵), anti-CD30L (□), or anti–4-1BBL (⋄) mAb (C and D) or control IgG (•, A–D) intraperitoneally at the time of infection and subsequently twice per week until the end of experiments. Net footpad swelling was measured by subtracting the thickness of the uninfected footpad from that of the infected footpad. Results are expressed as mean ± SD of six mice in each group. Similar results were obtained in two independent experiments.