Figure 5.

Requirement of IL-4 produced by Vα14 NKT cells for Con A–induced hepatitis. (A) MACS-sorted NK1.1⁺ spleen cells (10⁷) from B6, IL-4 KO, or IFN-γ KO mice were transferred intrasplenically into Vα14 NKT KO mice. 1 h later, the mice were injected with Con A (0.5 mg). The serum activities of ALT and AST were assessed 8 h after Con A injection. (B) Induction of Con A–induced hepatitis by adoptive transfer of cells from the Vα14 NKT cell line (2 × 10⁶). Three mice were used in each group. The mean values in triplicate with standard errors are shown.