Figure 7.

Requirement of FasL expression and perforin production from Vα14 NKT cells for Con A–induced hepatitis. MACS-sorted NK1.1⁺ spleen cells (10⁷) from B6, B6-gld/gld, or perforin KO mice were transferred intrasplenically into Vα14 NKT KO mice. 1 h later, the mice were injected with Con A (0.5 mg). 8 h later, the serum activities of ALT and AST were assessed. The mean values of triplicate samples with standard errors are shown.