Figure 2.

Adoptively transferred diabetes. 10 × 10⁷ diabetic DQ8⁺/mII⁻/B7⁺ splenocytes (depleted red blood cells) were transferred intravenously into irradiated recipients (as indicated). Diabetes was determined as above. Number of mice per group was as follows: n = 9 (4 female, 5 male) DQ8⁺/mII⁻/B7⁺; n = 8 (4 female, 4 male) DQ⁻/mII⁻/B7⁺; n = 3 (male) DQ8⁺/mII⁻/B7⁻; n = 3 (male) DQ8⁻/mII⁻/B7⁻; and n = 3 (male) DQ8⁺/mII⁻/B7⁺* (these recipients were adoptively transferred with purified CD8⁺ splenocytes only from diabetic DQ8⁺/mII⁻/B7⁺ mice).