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. 2000 Jan 3;191(1):77–88. doi: 10.1084/jem.191.1.77

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© 2000 The Rockefeller University Press

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Localization of lymphocytes in PP-HEVs. Micrographs of accumulated lymphocyte subpopulations in PPs. (Left panel) T cells accumulated in SLC⁺ interfollicular segments of HEVs. (Middle panel) B cells in SLC^low HEV segments associated with primary follicles. (Right panel) Segregation of sites of preferential T and B cell accumulation in relation to follicles. TRITC-labeled T (left) or B (middle and right panels) cells and CMFDA-labeled T cells (right panel) were observed in HEVs of normal animals as in the legend to Fig. 4. In the left and middle panels, after lymphocyte accumulation for ∼10 min (see Materials and Methods), 60 μg Alexa™ 488–conjugated anti-SLC mAb was injected intravenously to illuminate SLC-expressing HEV segments. Animals were killed, and whole PPs were removed for examination by confocal microscopy. The location of follicles is indicated (F) (20× objective).