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. 2000 Jan 3;191(1):171–180. doi: 10.1084/jem.191.1.171

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Effect of MC148 on chemotactic activity on THP-1 cells (monocytic cell line), PBLs, neutrophils, and CCR8-transfected L12 cells. To the left, dose–response curves for MC148 (▵). Dose–response curves (□) for MCP-1, SDF-1α, IL-8, and I-309 are shown for comparison. The bottom panel includes a dose–response curve for vMIP-II (○). To the right, dose–response curves for inhibition by MC148 (▴) of chemotaxis induced by 5 nM MCP-1 on THP-1 cells, 10 nM SDF-1α on PBLs, 10 nM IL-8 on neutrophils, and 10 nM I-309 on CCR8-transfected L12 cells. The bottom panel includes a dose–response curve for inhibition by vMIP-II (•). One representative assay out of three is shown for THP-1 cells, out of four for PBLs, out of three for neutrophils, and out of five for CCR8-transfected L12 cells.