Figure 1.

G and C nucleotides are preferentially mutated in Msh6⁻/− and Msh3⁻/−/Msh6⁻/− mice, but not in Msh3⁻/− or in heterozygous mice. The proportions of mutations in G and C bases, relative to those targeting A and T bases, are expressed as a percentage of the total mutations and are depicted as black and white bars, respectively. As discussed in the text, mutations in A and T are significantly fewer in Msh6⁻/− and Msh3⁻/−/Msh6⁻/− mice, compared with Msh3⁻/− or wild-type control mice. Base substitutions collected from both spleen and Peyer's patch GC B cells are combined in this figure. Results from heterozygous littermates of all three genotypes are pooled in this figure; details of each MMR littermate control can be found in Table Table Table . The wild-type sample represents data from Msh6⁺/+ control mice. These sequence data are available from GenBank under accession nos. AF183260–AF183322.