Table 1.
Mutation Frequency in the Anti-NP Response
| V sequences analyzed | Mutation frequency (×10−3) | |||||
|---|---|---|---|---|---|---|
| Total No. of sequences | Percent mutated sequences | Total No. of mutations | All sequences | Mutated sequences | ||
| Primary response | ||||||
| Msh3−/− | 35 | 71 | 91 | 9.3 | 13.0 | |
| Msh3+/− | 5 | 80 | 16 | 11.4 | 14.3 | |
| Msh6−/− | 16 | 69 | 36 | 8.0 | 12.0 | |
| Msh6+/− | 27 | 59 | 36 | 4.8 | 8.0 | |
| Msh3−/−/Msh6−/− | 30 | 50 | 30 | 3.6 | 7.1 | |
| Msh3+/−/Msh6+/− | 11 | 29 | 20 | 6.5 | 17.9 | |
| Secondary response | ||||||
| Msh6−/− | 22 | 5 | 1 | 0.2 | 3.6 | |
| Msh6+/− | 14 | 43 | 12 | 3.1 | 7.1 | |
Canonical V186.2 mutated regions and V186.2 analogues have been included in this analysis.