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. 2000 Feb 7;191(3):561–566. doi: 10.1084/jem.191.3.561

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Skin types I/II are more susceptible to UVR-induced immunosuppression than skin types III/IV. Analysis of individual (○, skin type I/II; •, skin type III/IV) and mean (▵, skin type I/II; ▴, skin type III/IV) slopes for CHS response shows that SSR exposure induced a highly significant dose-dependent suppression of cell-mediated immunity in all skin types (P < 0.001). CHS responses of skin types I/II were 5.3-fold lower than those of skin types III/IV throughout the dose range studied (P < 0.001; 95% CI 2.9–9.6).