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. 2000 Feb 7;191(3):529–540. doi: 10.1084/jem.191.3.529

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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p1–30 activity on PBMCs. (A) Proliferation of PBMCs. PBMCs from healthy human donors were stimulated with IL-2 (0.5 nM) or p1–30 (3, 30, 60, or 100 μM) for 3 or 6 d followed by measurement of thymidine incorporation. The graph shows the negative control (white bars), IL-2–induced proliferation (black bars), and the dose-dependent p1–30-induced proliferation (gray bars). (B) Induction of LAK cells. PBMCs stimulated with IL-2 (0.5 nM) or p1–30 (3, 10, 30, 60, or 100 μM) for 3 or 6 d were tested for their ability to lyse K562 or Daudi target cells. Percent lysis at different effector/target ratios is shown. (C) LAK cell induction by p1–31(Lys20). The lysis of K562 or Daudi target cells by PBMCs stimulated with p1–30 or p1–31(Lys20) (30 μM) for 6 d was measured. Results obtained at different effector/target ratios are presented. Data of representative experiments are shown.

p1–30 activity on PBMCs. (A) Proliferation of PBMCs. PBMCs from healthy human donors were stimulated with IL-2 (0.5 nM) or p1–30 (3, 30, 60, or 100 μM) for 3 or 6 d followed by measurement of thymidine incorporation. The graph shows the negative control (white bars), IL-2–induced proliferation (black bars), and the dose-dependent p1–30-induced proliferation (gray bars). (B) Induction of LAK cells. PBMCs stimulated with IL-2 (0.5 nM) or p1–30 (3, 10, 30, 60, or 100 μM) for 3 or 6 d were tested for their ability to lyse K562 or Daudi target cells. Percent lysis at different effector/target ratios is shown. (C) LAK cell induction by p1–31(Lys20). The lysis of K562 or Daudi target cells by PBMCs stimulated with p1–30 or p1–31(Lys20) (30 μM) for 6 d was measured. Results obtained at different effector/target ratios are presented. Data of representative experiments are shown.