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. 2000 Feb 7;191(3):529–540. doi: 10.1084/jem.191.3.529

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Activation of NK and CD8 T cells by p1–30 and induction of IFN-γ. (A) PBMCs were stimulated with IL-2 (0.5 nM) or p1–30 (10, 30, or 100 μM) for 1, 2, or 3 d. Subpopulations labeled with anti-CD4 (Th lymphocytes), CD8 (CTLs), CD20 (B lymphocytes), or CD56 (NK cells) were assayed for CD69 expression. Graphs represent the percentage of CD69⁺ cells for each population with respect to stimulant (IL-2 or p1–30) and time (day) of stimulation. Data of a representative experiment are shown. (B) IFN-γ production was measured on supernatants from PBMCs stimulated with IL-2 (0.5 nM) or p1–30 (30 μM) at day 6. In a second panel, synergy between IL-2 (0.5 nM) and p1–30 (30 μM) is shown after 2 d of stimulation.