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. 2000 Feb 21;191(4):703–716. doi: 10.1084/jem.191.4.703

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© 2000 The Rockefeller University Press

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(A) Schematic representation of parental and Lck/Fyn chimeric structures. wt, wild-type; U, unique. (B) Transforming efficiency of Src-PTKs in NIH-3T3 fibroblasts as measured in focus formation and soft agar growth assays. (C) Expression of transgene-encoded mRNAs in thymocytes from littermates representing indicated genotypes. Northern blot analysis using probes specific for the NH₂-terminal regions of Lck or the COOH-terminal regions of FynT (left), or probes specific for the COOH-terminal regions of Lck or the NH₂-terminal region of FynT (right). LF^Y, Lck-fyn chimera; FL^F, Fyn-lckF chimera; Tg, transgene. (D) Immunoblot (IB) analysis of chimera expression using antibodies specific for NH₂-terminal (NT) or COOH-terminal (CT) regions of p56^lck.

(A) Schematic representation of parental and Lck/Fyn chimeric structures. wt, wild-type; U, unique. (B) Transforming efficiency of Src-PTKs in NIH-3T3 fibroblasts as measured in focus formation and soft agar growth assays. (C) Expression of transgene-encoded mRNAs in thymocytes from littermates representing indicated genotypes. Northern blot analysis using probes specific for the NH₂-terminal regions of Lck or the COOH-terminal regions of FynT (left), or probes specific for the COOH-terminal regions of Lck or the NH₂-terminal region of FynT (right). LF^Y, Lck-fyn chimera; FL^F, Fyn-lckF chimera; Tg, transgene. (D) Immunoblot (IB) analysis of chimera expression using antibodies specific for NH₂-terminal (NT) or COOH-terminal (CT) regions of p56^lck.