Table 1.
Reconstitution of Lck−/− Thymopoiesis with Src-PTK Transgenes
| Transgenic line (Chimera) | Transgene mRNA | Genotype | n | No. of thymocytes |
|---|---|---|---|---|
| mean % ± SD | ||||
| A10247 | 0.18 | Lck-fyn | 11 | 89 ± 29 |
| (Lck-fyn) | lck −/− Lck-fyn | 5 | 1.9 ± 4 | |
| A10247 (2×) | 0.36 | Lck-fyn | 1 | 95 |
| (Lck-fyn) | lck −/− Lck-fyn | 2 | 11.5 ± 5 | |
| A10244 | 0.87 | Lck-fyn | 8 | 98 ± 38 |
| (Lck-fyn) | lck −/− Lck-fyn | 3 | 67 ± 24 | |
| A10262 | 4.45 | Lck-fyn | 5 | 67 ± 23 |
| (Lck-fyn) | lck −/− Lck-fyn | 5 | 56 ± 25 | |
| 490 | 1.02 | Lck-fynF | 9 | 131 ± 33 |
| (Lck-fynF) | lck −/− Lck-fynF | 3 | 98 ± 25 | |
| 116 | Fyn-lckF | 7 | 90 ± 32 | |
| (Fyn-lckF) | 0.96 | lck −/− Fyn-lckF | 4 | 2.1 ± 0.4 |
| 668 | Fyn-lckF | 5 | 120 ± 13 | |
| (Fyn-lckF) | 2.20 | lck −/− Fyn-lckF | 3 | 4.3 ± 1.0 |
| 687 | 3.50 | Fyn-lckF | 3 | 82 ± 24 |
| (Fyn-lckF) | lck −/− Fyn-lckF | 3 | 4.7 ± 1.8 | |
| 685 | 5.32 | Fyn-lckF | 7 | 132 ± 33 |
| (Fyn-lckF) | lck −/− Fyn-lckF | 8 | 12.9 ± 1.9 |