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Serum Ig levels in 4–8-wk-old SHIP wild-type (+/+), heterozygous (+/−), and knockout (−/−) mice. Serial dilutions of serum obtained from age-matched mice (n = 8–9) were used. Symbols represent levels in individual animals, and the bar represents the mean value. Statistical analysis was carried out using the Student's t test. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.005.
