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. 2000 Oct 16;192(8):1151–1164. doi: 10.1084/jem.192.8.1151

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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cDNA clones exhibiting multiple distinct secondary rearrangements using different heptamers. (A) Three distinct replacement events that occurred in the progeny of the parental ST1R M26 clone are listed below the original clone. Note that each clone used a different embedded heptamer to accomplish the replacement event. The most similar germline genes for M10 (1–69), M6 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18, and M31 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 are not listed. (B) Two distinct replacement events that occurred in the progeny (ST1R G1 and G2) of a V_H3–09–expressing B cell clone. It is clear that the original clone expressed a V_H3 gene because the nucleotides downstream from the embedded heptamer are identical to V_H 3-09 and are not found in any V_H1 family genes.