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. 2000 Oct 16;192(8):1151–1164. doi: 10.1084/jem.192.8.1151

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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graphic file with name JEM000726.f6ab.jpg — DNA clones exhibiting V_H replacements at the 5′ FR3 heptamer and the mid-position FR3 heptamer and at a heptamer embedded in HCDR2. (A) An example of a replacement that occurred at the 5′ FR3 heptamer. Note that there is another potential heptameric site located 12 bp upstream of the 5′ FR3 heptamer (highlighted in light gray). (B) An example of a replacement that occurred at the mid-position FR3 heptamer. (C) An example of a replacement that occurred at a heptamer located in HCDR2.

graphic file with name JEM000726.f6c.jpg — DNA clones exhibiting V_H replacements at the 5′ FR3 heptamer and the mid-position FR3 heptamer and at a heptamer embedded in HCDR2. (A) An example of a replacement that occurred at the 5′ FR3 heptamer. Note that there is another potential heptameric site located 12 bp upstream of the 5′ FR3 heptamer (highlighted in light gray). (B) An example of a replacement that occurred at the mid-position FR3 heptamer. (C) An example of a replacement that occurred at a heptamer located in HCDR2.