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. 2001 Feb 19;193(4):417–426. doi: 10.1084/jem.193.4.417

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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(A) Impaired GC formation in IKKα^2/− chimeras. IKKα^1/+ and IKKα^2/− RAG2-deficient B6 chimeras were immunized with alum-precipitated NP-CG and killed 14 d after injection. Splenic sections were stained with HE or immunostained with B220, anti-IgD, or PNA. (B) Impairment of splenic microarchitecture in IKKα^2/− chimeras. Frozen sections were stained with FDC-M1, F4/80, MOMA-1, or antisialoadhesin mAbs or rabbit anti–BST-1/Bp-3 antiserum. Scale bars, 200 μm.