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. 2001 Feb 19;193(4):531–544. doi: 10.1084/jem.193.4.531

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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BCL-2 cooperates with PMLRARα to impair neutrophil production in vivo. (A) Peripheral blood. White blood cell count (WBC, 1,000/μL), hemoglobin (HGB, g/dL), and platelet count (PLT, 100,000/μL) are shown. Littermate controls, n = 6; PMLRARα, n = 5; BCL-2, n = 4; and PMLRARα/BCL-2, n = 6. Platelet count was increased in PMLRARα/BCL-2 mice (P = 0.002). (B) Peripheral blood. Absolute cell counts (1,000/μL). Littermate controls, n = 6; PMLRARα, n = 4; BCL-2, n = 4; and PMLRARα/BCL-2, n = 6. Neutrophils were decreased in BCL-2 and PMLRARα/BCL-2 mice (P = 0.01). Monocytes were increased in PMLRARα/BCL-2 mice (P = 0.02). (C) Bone marrow. Percentages of nucleated cells were derived from 400 cell differential counts of Wright's Giemsa-stained bone marrow smears. Blast+Pro, blasts and promyelocytes; Imm Neut, neutrophilic myelocytes and metamyelocytes; Mat Neut, neutrophilic band, mature ring, and polymorphonuclear forms; Lymph, lymphocytes; Eosin, eosinophils. Littermate controls, n = 6; PMLRARα, n = 4; BCL-2, n = 4; PMLRARα/BCL-2, n = 6. In PMLRARα mice, blasts plus promyelocytes were increased (P = 0.01). In BCL-2 mice, blasts plus promyelocytes were increased (P = 0.02), immature neutrophils were increased (P = 0.04), and mature neutrophils were decreased (P = 0.02). In PMLRARα/BCL-2 mice, blasts plus promyelocytes were increased (P = 0.001), immature neutrophils were decreased (P = 0.003), mature neutrophils were decreased (P = 0.0004), and lymphocytes were decreased (P = 0.002). Graphs depict arithmetic means ± SD.

BCL-2 cooperates with PMLRARα to impair neutrophil production in vivo. (A) Peripheral blood. White blood cell count (WBC, 1,000/μL), hemoglobin (HGB, g/dL), and platelet count (PLT, 100,000/μL) are shown. Littermate controls, n = 6; PMLRARα, n = 5; BCL-2, n = 4; and PMLRARα/BCL-2, n = 6. Platelet count was increased in PMLRARα/BCL-2 mice (P = 0.002). (B) Peripheral blood. Absolute cell counts (1,000/μL). Littermate controls, n = 6; PMLRARα, n = 4; BCL-2, n = 4; and PMLRARα/BCL-2, n = 6. Neutrophils were decreased in BCL-2 and PMLRARα/BCL-2 mice (P = 0.01). Monocytes were increased in PMLRARα/BCL-2 mice (P = 0.02). (C) Bone marrow. Percentages of nucleated cells were derived from 400 cell differential counts of Wright's Giemsa-stained bone marrow smears. Blast+Pro, blasts and promyelocytes; Imm Neut, neutrophilic myelocytes and metamyelocytes; Mat Neut, neutrophilic band, mature ring, and polymorphonuclear forms; Lymph, lymphocytes; Eosin, eosinophils. Littermate controls, n = 6; PMLRARα, n = 4; BCL-2, n = 4; PMLRARα/BCL-2, n = 6. In PMLRARα mice, blasts plus promyelocytes were increased (P = 0.01). In BCL-2 mice, blasts plus promyelocytes were increased (P = 0.02), immature neutrophils were increased (P = 0.04), and mature neutrophils were decreased (P = 0.02). In PMLRARα/BCL-2 mice, blasts plus promyelocytes were increased (P = 0.001), immature neutrophils were decreased (P = 0.003), mature neutrophils were decreased (P = 0.0004), and lymphocytes were decreased (P = 0.002). Graphs depict arithmetic means ± SD.