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. 2001 Feb 5;193(3):281–296. doi: 10.1084/jem.193.3.281

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Por1A of FA19 and Por1B of MS11 are the acceptor molecules for C4bp. To demonstrate this for FA19 Por1A, we used pUNCH62 (reference 40) to replace F62 Por1B (C4bp nonbinder) with FA19 Por1A. The resultant strain, termed F62_PorFA19, bound C4bp in a flow cytometry assay when incubated with 10% NHS (left), indicating that FA19 Por1A was an acceptor molecule for C4bp. Similarly, using plasmid pUNCH61 (reference 40) we replaced F62 Por1B with MS11 Por1B, and observed that the isogenic mutant F62_PorMS11 bound C4bp (right), indicating that MS11 Por1B was an acceptor molecule for C4bp.