TABLE 1.
Genes with significantly different expression patterns in M. paratuberculosis- and nil-stimulated PBMCs from Johne's disease-positive cows
| Clone or gene | Identity or description | Mean fold change | P value |
|---|---|---|---|
| EMMPRIN | Amplicon representing bovine EMMPRIN mRNA | 1.74 | 0.00026 |
| BOTL0100003XB05R | Bovine EST clone weakly similar to human interferon-inducible guanylate binding protein 1 mRNA | 1.49 | 0.02938 |
| INF-γ | Amplicon representing bovine IFN-γ mRNA | 1.48 | 0.01185 |
| BOTL0100003XH04R | Bovine EST clone weakly similar to human putative LOC138179 mRNA | 1.38 | 0.00745 |
| GM-CSF-R-β | Amplicon representing bovine granulocyte-macrophage colony-stimulating factor receptor β mRNA | 1.29 | 0.00162 |
| BOTL0100003XF09R | Bovine EST clone highly similar to human leukocyte antigen-related protein mRNA | 1.28 | 0.03403 |
| BOTL0100012_C05 | Bovine EST clone weakly similar to human nuclear autoantigen (SP-100) mRNA | −1.27 | 0.02860 |
| BOTL0100010_A07 | Bovine EST clone highly similar to a gene from COS-1 cells affected by herpes simplex virus type 1 | −1.37 | 0.03951 |
| BOTL0100003XD01R | Bovine EST clone similar to human nucleoside diphosphate-linked moiety X-type 3 (NUDT3) mRNA | −1.37 | 0.02034 |
| Inhibin-A | Amplicon representing bovine inhibin A subunit mRNA | −1.39 | 0.00574 |
| CD4 antigen (p55) | Amplicon representing bovine CD4 antigen p55 subunit mRNA | −1.46 | 0.04854 |
| Flk-1 | Amplicon representing bovine bovine Flk-1 tyrosine kinase receptor mRNA | −1.65 | 0.01075 |
| IL-6 Rα | Amplicon representing bovine IL-6 receptor α-chain mRNA | −1.71 | 0.02903 |
| CYCB2 | Amplicon representing bovine cyclin B2 mRNA | −2.30 | 0.00124 |
| MMP9 | Amplicon representing bovine MMP 9 mRNA | −2.41 | 0.02458 |
| Sentrin | Amplicon representing bovine sentrin mRNA | −3.20 | 0.04328 |