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. 2001 Feb 5;193(3):271–280. doi: 10.1084/jem.193.3.271

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© 2001 The Rockefeller University Press

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Radioautograph of multiprobe RPA run using ³⁵S-labeled probes to detect mRNA for IFN-γ, NOS2, IL-4, IL-13, IL-15, and IL-2Rα in the lungs of WT and TCR-α/β^−/− mice on days 0, 10, 20, 30, and 50 of infection. The results clearly show upregulation of mRNA for NOS2 and IFN-γ from day 20 of infection in WT mice. Much less IFN-γ mRNA was present in the lungs of TCR-α/β^−/− mice from day 30 on, and the production of NOS2 mRNA was delayed. IL-15 mRNA was constitutively produced in the lungs of both groups of mice, and its synthesis appeared to be little altered by infection. GAPDH, glyceraldehyde 3-phosphate dehydrogenase.