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. 2001 Sep 3;194(5):677–684. doi: 10.1084/jem.194.5.677

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© 2001 The Rockefeller University Press

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Inflammation in the peripheral nervous system in neuropathic B7-2^−/− NOD mice. Hematoxylin and eosin staining on sections of pancreas (a and b), brain cortex (c and d), spinal cord (e and f), dorsal root ganglion (g and h), and sciatic nerve (i and j) in 25–30-wk-old B7-2^−/− neuropathic females (b, d, f, h, and j) and age-matched B7-2^+/+ control females (a, c, e, g, and i). (a–d and f–j) Original magnification: ×500. (e and f) Original magnification: ×250. B7-2^+/+ mice, but not B7-2^−/− mice, exhibit severe insulitis (a) whereas B7-2^−/− mice, but not B7-2^+/+ mice, exhibit inflammation in dorsal root ganglions (h) and nerves (j).