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. 2001 Sep 3;194(5):557–570. doi: 10.1084/jem.194.5.557

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Functional activity of the DTA transgene. (A) In vitro activation of the DTA gene by cell fusion. Percentage of hybridoma growth from wt, JDTA heterozygous (JDTA^+/−), and JDTA day 2 LPS-stimulated splenic B cells fused with SP2/0 and plated at different SP2/0 cell densities. (B) Deletion of J chain–expressing cells in vivo. Serum IgA from wt, JDTA heterozygous, and JDTA mice were separated on a nondenaturating polyacrylamide gel and detected by immunoblotting.