Figure 10.

Effects of sTGFβR-Fc and aprotinin on IL-13–induced fibrosis. In the panels on the left 1 mo-old IL-13 transgene (+) mice were treated with sTGFβR-Fc or control and collagen was assessed with trichrome stains. Comparisons are made of WT littermate transgene (−) control mice (A), transgene (+) mice that received control IgG (B), and transgene (+) mice that received sTGFβR-Fc (C). In the panels on the right Sircol biochemical assays were used to characterize the effects of sTGFβR-Fc or aprotinin on lung collagen content. Comparisons are made of WT littermate transgene (−) control mice, transgene (+) mice that received appropriate controls (IL-13) and transgene (+) mice that received sTGFβR-Fc (+ sTGFβR-Fc) or aprotinin (+ aprotinin). Each bar represents the mean ± SEM of a minimum of four animals. *P < 0.01.