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. 2001 Nov 5;194(9):1339–1348. doi: 10.1084/jem.194.9.1339

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Copyright © 2001, The Rockefeller University Press

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Figure 9. — B7H expression increased susceptibility of established tumors to T cell therapy. J558-Neo and J558-B7H tumors were allowed to grow in the BALB/c^rag-2−^/− mice for three weeks until they reached ∼1.5 cm in diameter. Transgenic T cells (5 × 10⁶/mouse) were then injected intraperitoneally. (A) Tumor size after T cell injection. Note the complete disappearance and recurrence of the J558-B7H tumors. *, found dead; ** moribund and killed. (B). Mechanism of tumor recurrence. Analysis of cell surface expression of MHC class I H-2L^d, and B7H. Left, a J558-B7H cell line as control. Middle, phenotype of the J558-B7H-A tumor cells. Right, phenotype of the J558-B7H-B tumor cells.

Figure 9. — B7H expression increased susceptibility of established tumors to T cell therapy. J558-Neo and J558-B7H tumors were allowed to grow in the BALB/c^rag-2−^/− mice for three weeks until they reached ∼1.5 cm in diameter. Transgenic T cells (5 × 10⁶/mouse) were then injected intraperitoneally. (A) Tumor size after T cell injection. Note the complete disappearance and recurrence of the J558-B7H tumors. *, found dead; ** moribund and killed. (B). Mechanism of tumor recurrence. Analysis of cell surface expression of MHC class I H-2L^d, and B7H. Left, a J558-B7H cell line as control. Middle, phenotype of the J558-B7H-A tumor cells. Right, phenotype of the J558-B7H-B tumor cells.