Table I.
Baseline Characteristics of Study Subjects and Their Estimated Values of CD4+ and CD8+ Lymphocyte Proliferation (p), Death (d), and Fractional Input from a Source (
U)
| Baseline values
|
CD4+
|
CD8+
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subjects | Age(sex) | Plasma viral load | CD4+ | CD8+ | p(95% CI) | d(95% CI) |
U(95% CI) |
p(95% CI) | d(95% CI) |
U(95% CI) |
| (copies/ml) | μl−1 | μl−1 | day−1 | day−1 | day−1 | day−1 | day−1 | day−1 | ||
| Controls: | ||||||||||
| C1 | 43 (M) | - | 880 | 562 | 0.005 (0.005-0.006) |
0.057 (0.024-0.110) |
0.044 (0.016-0.094) |
0.004 (0.003-0.005) |
0.076 (0.044-0.139) |
0.072 (0.041-0.134) |
| C2 | 22 (F) | - | 992 | 576 | 0.004 (0.003-0.011) |
0.064 (0.024-0.496) |
0.060 (0.020-0.485) |
0.002 (0.002-0.003) |
0.018 (0.013-0.090) |
0.016 (0.011-0.087) |
| C3 | 22 (F) | - | 1,366 | 651 | 0.003 (0.001-0.131) |
0.013 (0.002-10.9) |
0.010 (0.000-10.7) |
0.002 (0.001-0.006) |
0.008 (0.002-1.36) |
0.006 (0.000-1.34) |
| C4 | 22 (M) | - | 1,066 | 621 | 0.004 (0.003-0.005) |
0.042 (0.029-0.120) |
0.020 (0.013-0.065) |
0.002 (0.002-0.003) |
0.070 (0.016-0.196) |
0.067 (0.014-0.192) |
| Mean ± SE | 30.0 | - | 1,076 | 603 | 0.004 ± 0.0005 | 0.044 ± 0.011 | 0.033 ± 0.011 | 0.003 ± 0.0004 | 0.043 ± 0.017 | 0.040 ± 0.017 |
| Infected: | ||||||||||
| P1 | 38 (M) | 500,000 | 322 | 806 | 0.033 (0.028-0.041) |
0.112 (0.071-0.167) |
0.077 (0.045-0.123) |
0.036 (0.033-0.040) |
0.065 (0.038-0.090) |
0.046 (0.025-0.078) |
| P2 | 24 (M) | 226,087 | 255 | 494 | 0.034 (0.027-0.042) |
0.135 (0.086-0.255) |
0.100 (0.056-0.214) |
0.018 (0.015-0.022) |
0.092 (0.064-0.272) |
0.074 (0.049-0.249) |
| P3 | 26 (M) | 7,629 | 323 | 617 | 0.010 (0.009-0.010) |
0.042 (0.025-0.068) |
0.050 (0.034-0.081) |
0.010 (0.009-0.011) |
0.029 (0.018-0.072) |
0.031 (0.020-0.077) |
| P4 | 46 (F) | 61,946 | 48 | 323 | 0.039 (0.036-0.047) |
0.082 (0.053-0.131) |
0.042 (0.016-0.086) |
0.024 (0.022-0.029) |
0.032 (0.024-0.059) |
0.008 (0.003-0.032) |
| P5 | 38 (M) | 88,997 | 804 | 1,148 | 0.019 (0.015-0.160) |
0.306 (0.153-3.8) |
0.285 (0.137-3.61) |
0.029 (0.026-0.035) |
0.062 (0.034-0.157) |
0.022 (0.012-0.072) |
| P6 | 21 (M) | 13,367 | 626 | 1,312 | 0.016 (0.014-0.019) |
0.151 (0.095-0.214) |
0.240 (0.115-0.641) |
0.024 (0.023-0.026) |
0.049 (0.038-0.067) |
0.024 (0.015-0.041) |
| P7 | 36 (F) | 22,410 | 337 | 1,011 | 0.022 (0.021-0.023) |
0.077 (0.060-0.093) |
0.065 (0.045-0.079) |
0.017 (0.016-0.019) |
0.022 (0.015-0.060) |
0.011 (0.007-0.050) |
| Mean ± SE | 32.6 | 131,491 | 388 | 816 | 0.025 ± 0.004a | 0.129 ± 0.033a | 0.123 ± 0.037a | 0.023 ± 0.003a | 0.050 ± 0.009 | 0.031 ± 0.009 |
CI, confidence interval.
a
Mean values in infected patients that are significantly different (P value <0.05 by Wilcoxon rank sum U-test) from those in normal persons.