Table I.

Inflammatory Changes in Colon and Spleen after DSS Administration

		Colon length	Colon weight/length ratio	Spleen weight
		cm	mg/cm	% body weight
WT	plus water	7.3 ± 0.2b&e b–e	35.9 ±1.7b&e b–e	0.31 ± 0.02b,e
WT	plus DSS	4.8 ± 0.2a,c	65.9 ± 3.5a,c	0.54 ± 0.04a,c
iNOS−/−	plus DSS	5.9 ± 0.2a,b,e	51.3 ± 2.1a,b	0.33 ± 0.02b,e
p47phox−/−	plus DSS	5.3 ± 0.1a	59.5 ± 4.8a	0.39 ± 0.05e
SODTg	plus DSS	4.7 ± 0.2a , c	62.6 ± 2.2a	0.65 ± 0.05a,c,d
WT (conv.)	plus DSS	5.2 ± 0.3	58.0 ± 4.6	0.51 ± 0.06
iNOS−/−	plus DSS	6.4 ± 0.3f	45.4 ± 4.2f	0.30 ± 0.03f

Colon and spleen changes after 7 d of oral treatment with either water in WT or DSS in WT, iNOS^−/−, p47phox^−/−, and SOD^Tg mice (n = 9/group). In addition DSS-treated WT versus iNOS^−/− mice under conventional housing conditions (n = 5/group). Mean ± SEM.

^a P < 0.05 vs. WT plus water.

^b P < 0.05 vs. WT plus DSS.

^c P < 0.05 vs. iNO^−/− + DSS.

^d P < 0.05 vs. p47phox^−/− plus DSS.

^eP < 0.05 vs. SOD^Tg plus DSS.

^f P < 0.05 vs. WT (conv.) plus DSS.