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. 2001 Feb 5;152(3):425–434. doi: 10.1083/jcb.152.3.425

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Microtubule attachment to kinetochores in microinjected cells. CFPAC-1 cells that were uninjected (A) or microinjected with antibodies to both NuMA and HSET (B) were processed for transmission electron microscopy. Arrows in A and B point to centrosomes. The electron-dense material detected in B near the centrosomes is most likely the antibody-induced aggregates of NuMA and HSET, which are prominently detected by immunofluorescence microscopy. (C) High magnification views to highlight kinetochore-microtubule interactions in the chromosomes identified as 1–4 in B. The kinetochore regions of chromosome 2 were located in the adjacent serial section from that shown in B. Bars: (A and B) 3 μm; (C) 100 nm.