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. 2001 Feb 5;152(3):621–632. doi: 10.1083/jcb.152.3.621

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Biochemical responses towards cAMP in torA ⁻. Cells were developed for 5 h in a shaken suspension with the addition of 100-nM pulses of cAMP every 6 min or on DB-agar plates (in the case of cGMP accumulation) (A) Signal transduction responses: 5 × 10⁻⁵ M 2′deoxy-cAMP (cAMP accumulation), 10⁻⁷ M cAMP (F-actin), 10^-6 M cAMP (cGMP accumulation). •, torA ⁻; ▪, Ax3; ▴, mek1 ⁻. (B) Translocation of Crac PH-domains to the leading edge of torA ⁻ and wild-type cells in a cAMP gradient. The white dot indicates the position of the micropipette filled with 10⁻⁶ M cAMP. Bar, 10 μm.