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. 1997 Feb 3;185(3):439–452. doi: 10.1084/jem.185.3.439

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Modulation of downregulatory activity by addition or neutralization of known cytokine regulators during restimulation of B10.BR T cells with either B10.BR or B10.A splenic APC. B10.BR T cells (TCL 4) were restimulated with mMBP Ac1-16 and either B10.BR or B10.A splenic APC for 24 h in the absence or presence of mouse recombinant IL-4, IFN-γ, TNF-α, and IL-12 alone or combination with neutralizing antibody specific for mouse IL-12, or mouse IL-4. Cytokine levels resulting from each treatment are expressed as a percentage of control (B10.BR TCL, B10.BR APC, and peptide with no cytokine or antibody additions). Data presented are means and standard deviations of triplicate wells for each sample (n = 3). At least two independent experiments were performed for each treatment, yielding similar results.