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. 1997 Feb 3;185(3):563–572. doi: 10.1084/jem.185.3.563

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Schematic representation of mutations in rearranged VH5-μ sequences. Each line represents one VH5 sequence. VH5-2 sequences are underlined. Leader region, CDR1, and CDR2 are indicated. Mutations present in the DJH regions are not shown. Mutations are represented by different symbols. •, replacement mutation; ‖, silent mutation; ○, stop codon. (A and B) VH5-μ sequences from slgM⁺IgD⁺CD38⁻ B cells and sIgM⁺IgD⁺CD38⁺ B cells, respectively. The upper, middle, and lower groups of sequences represent three different tonsil samples. (C and D) VH5-μ sequences from medium-sized and large sIgM⁺IgD⁺CD38⁺ B cells, respectively, that were isolated from the fourth tonsil.

Schematic representation of mutations in rearranged VH5-μ sequences. Each line represents one VH5 sequence. VH5-2 sequences are underlined. Leader region, CDR1, and CDR2 are indicated. Mutations present in the DJH regions are not shown. Mutations are represented by different symbols. •, replacement mutation; ‖, silent mutation; ○, stop codon. (A and B) VH5-μ sequences from slgM⁺IgD⁺CD38⁻ B cells and sIgM⁺IgD⁺CD38⁺ B cells, respectively. The upper, middle, and lower groups of sequences represent three different tonsil samples. (C and D) VH5-μ sequences from medium-sized and large sIgM⁺IgD⁺CD38⁺ B cells, respectively, that were isolated from the fourth tonsil.