Table 4.
Comparison of the Binding Constants for the Interactions of the TCR, CD2, CD4, and CD28 with Their Respective Ligands
| Interaction | kon (M−1s−1) | koff (s−1) | K d * (μM) | References | ||||
|---|---|---|---|---|---|---|---|---|
| TCR binding peptide–MHC | ||||||||
| 2B4 TCR–MCC peptide plus I-Ek | 900–1,700 | 0.057–0.09 | 5–50 | (70, 71) | ||||
| 2C TCR–p2C peptide plus Ld | 11,000–210,000 | 0.006–0.026 | 0.1–0.5 | (72, 73) | ||||
| 42.12 TCR–OVA peptide plus Kb | 3,100 | 0.02 | 7–19 | (22) | ||||
| CD2–CD58 | ⩾400,000 | ⩾4 | 9–22 | (27) | ||||
| CD4–MHC class II | − | − | ⩾3 | (74, 75) | ||||
| CD28–CD80 | ⩾660,000 | ⩾1.6 | 4 | Present study |
*
K d values shown were obtained by equilibrium binding, but the range of K d values shown for TCR interactions includes some values calculated from the koff and kon.