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. 1997 Feb 3;185(3):415–428. doi: 10.1084/jem.185.3.415

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The effect of oral and parenteral administration of rmIL-12 on mucosal IgA responses to an oral vaccine consisting of TT and CT as mucosal adjuvant. TT-specific S-IgA Ab titers in fecal extracts were measured on day 21 by ELISA. The frequency of TT-specific IgA AFCs in LPLs was determined on day 21 by ELISPOT. Mice received the oral vaccine alone (unshaded) or together with rmIL-12 by i.p. injection (striped, 100 ng/dose) or six oral administrations (shaded, 1,000 ng/dose). The results are expressed as the mean ± one SD from four different experiments (five mice per group).