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. 2002 Aug 19;196(4):505–515. doi: 10.1084/jem.20020556

Figure 6.

Figure 6.

T cell–derived IL-10 mediates the disease-protective effect of WT CD45RBlow CD4+ cells. (A) Infected RAG/IL-10 double deficient mice were given either no cells or infected IL-10 KO CD4+ cells and infected WT CD4+ CD45RBlow cells as indicated (4 × 105 of each population) and then treated with control mAb or anti–IL-10R mAb for 4 wk. Bars represent mean cecal histology scores ± SD of three mice per group. (B) Infected RAG KO mice (solid bars) were inoculated with CD4+ cells from infected IL-10 KO, WT, and IL-4 KO mice as indicated (3 × 105 of each population) and then treated with control mAb or anti–IL-10R mAb for 4 wk. Naive (open bar) and infected RAG KO animals receiving no cells were included as controls. Bars represent mean cecal histology scores ± SD of three mice per group from one representative experiment out of two performed. Statistical significance was tested for groups receiving IL-10 KO cells. *, P < 0.05 compared with mice receiving infected IL-10 KO cells alone.