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. 2002 Aug 19;196(4):447–457. doi: 10.1084/jem.20020052

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Copyright © 2002, The Rockefeller University Press

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Figure 11. — Sensitivity of T, B, NK cells and DCs to tryptophan metabolites. T, B, and NK cells were separated from PBMCs and DCs were generated as described previously. The cells were incubated with a metabolite mixture (kynurenine plus 3-hydroxykynurenine plus anthranilic acid plus 3-hydroxyanthranilic acid plus quinolinic acid) (concentrations: 0, 8, 16, 32 μM for each metabolite). The percentage of dead cells (ordinate) was measured by 7-AAD-staining every day (abscissa).