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. 2002 Aug 19;196(4):447–457. doi: 10.1084/jem.20020052

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Copyright © 2002, The Rockefeller University Press

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Figure 7. — Effect of IDO-induced tryptophan metabolites on T cell proliferation. Peripheral lymphocytes were stimulated with anti-CD3 antibody for 3 d in the presence of various amounts (abscissa) of (A) 3-hydroxykynurenine, (B) anthranilic acid, (C) 3-hydroxyanthranilic acid, or (D) quinolinic acid. Positive control consisted of T cell stimulation in the absence of metabolites. T cell proliferation was determined by ³[H]thymidine incorporation (cpm) (ordinate).