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. 2002 Dec 16;196(12):1645–1651. doi: 10.1084/jem.20021340

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Copyright © 2002, The Rockefeller University Press

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Figure 3. — TLR4d mice sensitized intraperitoneally with the adjuvant aluminum hydroxide are capable of generating Th2 responses to OVA. (A) WT and TLR4d were primed either intranasally with OVA or intraperitoneally with OVA in alum and BAL was evaluated on day 21 after standard intranasal challenge. Stacked bars of cell differential are shown. Total BAL cell number is represented by height of stacked bars and standard error is based on total BAL number. *, P < 0.005 (intranasally primed TLR4d vs. WT mice). Mice immunized intraperitoneally with alum alone did not respond. (B) Cytokine production in pg/ml from DLN of intranasally or intraperitoneally primed WT (solid bars) or TLR4d (open bars) mice. ND, not detectable. IFN-γ was not detectable from cultures of WT or TLR4d mice primed intranasally or intraperitoneally with OVA containing a low dose of LPS. One representative experiment of two is shown.

Figure 3. — TLR4d mice sensitized intraperitoneally with the adjuvant aluminum hydroxide are capable of generating Th2 responses to OVA. (A) WT and TLR4d were primed either intranasally with OVA or intraperitoneally with OVA in alum and BAL was evaluated on day 21 after standard intranasal challenge. Stacked bars of cell differential are shown. Total BAL cell number is represented by height of stacked bars and standard error is based on total BAL number. *, P < 0.005 (intranasally primed TLR4d vs. WT mice). Mice immunized intraperitoneally with alum alone did not respond. (B) Cytokine production in pg/ml from DLN of intranasally or intraperitoneally primed WT (solid bars) or TLR4d (open bars) mice. ND, not detectable. IFN-γ was not detectable from cultures of WT or TLR4d mice primed intranasally or intraperitoneally with OVA containing a low dose of LPS. One representative experiment of two is shown.