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. 2003 Jul 7;198(1):71–78. doi: 10.1084/jem.20022119

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Immunohistology of the CNS in animals treated with PD-1 blockade. Spinal cord sections from WT and CD28-deficient animals treated with anti–PD-1 or control antibody were obtained on day 14 after immunization and stained with anti-CD4, anti-CD8, and anti-F4/80. There is a visible increase in the number of CD4⁺ and CD8⁺ T cells as well as the macrophages (F4/80⁺ cells) in the anti–PD-1–treated mice, compared with controls in both the WT and CD28-deficient animals, more apparent in the former (×200).