Figure 6.
PD-L1 expression is down-regulated on stimulated splenocytes of older NOD mice. Expression of PD-L1 on CD3+ (A and B) or CD3− (C and D) splenocytes of female NOD (A and C) or BALB/c (B and D) mice of various ages before and after stimulation with immobilized anti-CD3 mAb for 72 h. *, P < 0.01 and **, P < 0.05 versus stimulated CD3+ cells from 9-wk-old female NOD mice.