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. 2003 Jul 7;198(1):161–171. doi: 10.1084/jem.20030097

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Copyright © 2003, The Rockefeller University Press

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Figure 8. — Capacity of ocular PE to suppress activation of T cells from mice with disrupted CD28 and CTLA-4 (CD152) genes. PE were cultured from iris, ciliary body, and retina of C57BL/6 mice and used as substrates for purified T cells prepared from the spleens of 22-d-old wild-type mice, 22-d-old CTLA-4^−/− mice, and 6-wk-old CD28^−/− mice. The T cells were stimulated with anti-CD3 antibodies at concentrations of (A) 0.5 and (B) 1.0 μg/ml. Cultures were terminated at 72 h and [³H]thymidine incorporation was assessed. Mean counts per minute for triplicate cultures are presented ± SEM. Differences of means of T cell proliferation in the presence or absence of PE cells are compared. *, P < 0.05; **, P < 0.005; ***, P < 0.0005; NS, not significant.