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. 2003 Jul 7;198(1):145–151. doi: 10.1084/jem.20022129

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — Induction of systemic anaphylaxis results in PAF-associated biphasic anaphylaxis. (a) Biphasic increase in hematocrit (Ht) values during anaphylaxis and its inhibition by the PAF antagonists WEB 2170 (□) and CV 6209 (▵) administered 10 min before challenge injection. ○, control group. (b) Inhibition of the late phase increase in hematocrit values by WEB 2170 (□) and CV 6209 (▵). They were administered 6 h after challenge injection. ○, control group. (c) Biphasic increase in plasma PAF levels during anaphylaxis. Results for all panels are expressed as the mean ± SEM of three to seven separate experiments (n = 4 for each time point). *, P < 0.05; **, P < 0.01 versus control. Statistical significance was determined by Mann-Whitney U test.