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. 2003 Jul 7;198(1):145–151. doi: 10.1084/jem.20022129

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — Mast cells are not involved in the late phase of anaphylaxis. (a) Time course of plasma histamine levels after challenge in C57BL/6 mice. (b) The late phase increase in plasma PAF and hematocrit value in W/W^v mice. Blood was collected 7.5 h after challenge injection. (c) Comparison of serum levels of TNF-α between +/+ and W/W^v mice during anaphylaxis. Blood was collected 80 min after challenge injection. (d) Inhibition of the second phase of increase in hematocrit value by anti–TNF-α Ab. 2 mg/mouse Ab was injected i.p. 45 min after challenge injection. Results for all panels are expressed as the mean ± SEM of three separate experiments (n = 3 for each time point). P < 0.01 versus control; Mann-Whitney U test.